So what ouputs are there in humans that have been proven different between individuals that point to efficiency variation?
A out of shape person and in shape person, both 170 lbs @ 30% fat, run a mile. In-shape person is less out of breath b/c their body uses oxygen more efficiently, which means their lungs have done less work, which means that fewer calories are expended for the same amount of activity. The actual difference in oxygen utilization can be quantified by measuring VO2 max.
So where is the energy going to? Is there a lower body temperature for example that would require less energy to maintain? The energy has to be accounted for somehow.
I don’t know, and clearly science hasn’t gotten it figured out either. The point I was trying to make is that when calories in and calories out are accounted for and show a deficit, and the body in question is not losing mass, then that is not a violation of physics. It is a reality that the calories in/calories out model can’t explain.
The calories in/calories out model is accurate for some people, just as the ideal gas law is accurate for some gases. But simplified models have limits, which is why someone saying, “I did it, therefore it’s possible,” means essentially nothing except that the model describes them accurately.
If a model doesn’t describe reality, as in the case of people who have diligently applied calories in/calories out to lose weight and have failed, you don’t deny reality. You come up with a better model.

