There are scant real world tests of these packs, especially with significant weight—or long duration. Like some guy using one for a year in all conditions on expedition type trips with around 75 lbs of weight.
Was searching this forum for information on large mids and tipis, came across this thread, read it, and figured I’d weigh in with my experience carrying these packs since it’s fairly extensive and this discussion was 90% about buckles from people that haven’t even used the packs.
As background, I have ~120 nights on a Seek Outside Revolution frame with loads ranging from 20 pounds while summer recliner backpacking to 110 pounds packing out an elk this fall that I shot 8.5 miles from the car. I also carried a Divide for ~30 nights prior to selling it here on BPL and buying a Revolution. I’ve backpacked over the years in Osprey, ULA, HMG, and Zimmerbuilt packs as well. Two of my friends also carry Seek Outside packs after having packed animals alongside me and they agree.
From what my friends and I know and have tried, there isn’t a better frame system at this weight, for all loads, than these packs. They carry everything extremely well. A 30 pound load in my Revolution feels dramatically better on my back than a 30 pound load in my Circuit, and so I find myself either covering identical distances with a two pound heavier load more enjoyably, or carrying more of the fun stuff—fresh foods, beer, a klymit dinghy and paddle, hammock, etc—just as comfortably.
Since this frame works so well, the extra weight is worth it in the vast majority of circumstances. Thruhiking long trails may be one of the only exceptions where pack weight matters more over the long run. Sure, they don’t have the aesthetic flashiness of a lot of brands, but what you get for the money is a practical backpack that will carry basically anything you put in it more comfortably than any other backpack ever discussed on this forum.
Here I am very unhappily carrying my boots and pants, bow, two elk legs, and my backpacking gear with a couple days of food barefoot on numb feet after crossing a creek. But, the frame isn’t collapsed, load lifters are well above my shoulders, and everything is working. After a 7 mile carry in a single go, I had no bruising or hot spots.

If it works well in that scenario, you can bet your ass it’s comfortable with typical ultralight loads.