I think it is too difficult to generalize. There are just too many factors.
I have seen people doing 30+ miles day in and day out with both frameless and framed backpacks (1.5 lbs, 2 lbs, 3lb backpacks) on the PCT – for days/months without any issues. I am assuming you will not be able to do this if you were spending too much energy every day that made you tired more than usual.
Personally, I carried a frameless and 5 lbs in hip packs/fanny packs and didn’t have any shoulder pain or spine issues with 27-30 miles every day – multiple multiple days on the trail. I have been using a frameless for the past several years. The only comparison point I have is the hills on JMT were easier with frameless compared to framed (Sierra Designs Flex Capacitor – which is a 2.5 lbs backpack). That was my observation.
There are no rules. It is more important to have something that fits you properly which will prolong the joy of carrying the backpack. I had several frameless packs that I could have chosen – 12 oz Nero, 14 oz MLD Prophet etc. But, I took a 25 oz XPAC frameless pack because it carried better with 4 liters of water. Conventional wisdom would have said – take the lighter backpack.
There was a craze in biking as well – where bicycle frame weights were getting very low using carbon fiber and I spent multiple thousands of dollars getting the lightest frame, lightest components, lightest wheels. When a person goes to a lower weight bicycle – the first few rides you will notice the weight difference and all the reviews are written during that honeymoon period. But in a month, your average speed will be the same as before. My average speed has been the same irrespective of what bike weight bike I ride. In fact, with a heavier bike which was *fitted* properly to me, I did better averages with less effort.
I don’t like tapered packs which become wider and deeper at shoulder level – it seems counter-intuitive. Our spines are S shaped and go outward near the shoulder blades – so having something deeper, wider will mean more stuff hanging away from shoulders – which is probably why such backpacks need load lifters to pull it back in towards your back. And if you are carrying heavier weight near the shoulders, it will be amplified more. Which is when load lifter are so crucial for such backpacks.