Yeah, as Justin and Roger were saying, wool socks are best for wet conditions. I spent over 6 weeks doing the Northern Forest Canoe Trail lining the canoe through some tough water. In two places I was making only 5-6 miles (as the crow flies, more on the twisting creeks.) I got one blister on the front of my big toe after a 4 day stretch of lining up one of the creeks in Vermont, even wearing sandals. Sandals are not that great since they pick up all sorts of debris: sticks, sand, pebbles, mud, etc. I met my wife and she brought me some mids to continue the hike. Yup, they still soaked up water, but at least they did not pick up debris.
Wool socks, even walking through water, are a big help as is drying out every night. They supply good cushioning even when soaked in water…when you need it most. Proper socks works better than all the salves, creams or oils. Darn Tough, Smart Wool, Wig Wam, or the like, they all perform the same.
Actually, except for short hikes, every hike I have been on means wet feet at least at some point. Especially with trail runners. They wet out in the scrub in the mornings. One of the reasons I switched back to mids with a heavy scree collar. They do not wet out as easily nor pick up mud from ankle deep mud holes or beaver ponds. It is something we deal with in the NE. I don't even worry about it. I know my feet can handle it. I don't treat with anything, just heavy socks and an anticipation of wet feet.