Look at the typical weather and climate averages (sun, rain, snow, winds, .. lightning .. but also hurricanes have interrupted late AT trips in the American south), but also be on the lookout for extremes/other patterns.
Then there’s alternate plans considering right now the American NE is getting inundated with smoke which has been the case in the American West … usually.  An old Backpacker magazine recommendation was plan for 200 miles the opposite direction in case weather disrupted plans, but maybe now (for long trips)  it’s look at the other side of the country?  Planes, trains, etc..
Example 1:
El Niño is making an early comeback for 2023 that could open the door for even more extreme weather in the last part of the year
https://www.accuweather.com/en/climate/el-nino-is-officially-underway-heres-what-that-means-for-the-weather/1538335
(seeing this every from the Los Angeles Times to Oklahoma news .. so choose your geography).
Another El Niño may mean a big storm in the late spring or even early summer desert for instance.
Example 2:
Hotter weather year over year is resulting in rattlesnakes coming out early …
https://www.nbclosangeles.com/news/socal-wil-see-more-rattlesnakes-this-year-heres-what-to-do-to-stay-safe/3143146/
and likely more numbers as temps in the upper 80°F is optimal for their digestion.  So there’s keeping an eye out, but also realize overgrown trails make this a little tricky if they don’t rattle.   If ssssnakey encounters rattle you (ok, pun intended), maybe plan SoCal and Arizona trips more towards the dead of winter (taking appropriate gear and clothing of course).