This is a really complicated topic but I will attempt to wade in.
As it pertains to the pack “beating up” your body, my opinion is that weight spent on reducing this is generally poorly spent, but certainly you need the right tool for the job.
A pack can “beat up” your body in many ways, so to start we need to broadly categorize that. l think of it in three areas – these are effects on (1) posture, (2) pressure points and (3) wear on legs. For examples, a pack with a trampoline back has a negative effect on your posture because it requires leaning forward more, a pack with a poor frame or cushioning won’t distribute the weight ideally so you get sore pressure points (e.g. shoulders) and lastly, even a hypothetical pack that perfectly fits you and transfers the load with maximum comfort, still takes a toll on your legs because they have to carry that weight every step of the way. A key point I want to make is I think pack discussion in general puts too much emphasis on #2, and not enough on #3.
When I say that “My opinion is that weight spent on “comfort” in a pack is generally poorly spent”, I am speaking in the context of UL hiking and what I mean is that the benefits that folks often cite do not justify the weight increase in many instances. Often they are justifying the inclusion of features that might be helpful in some contexts but are often overkill like buying a Ford F-150 to bring home the groceries.
A few examples are:
1) The hipbelts on the Seek Outside packs are massively padded and quite heavy (relatively speaking). The potential advantage is better load distribution, but I am more than pleased with the load distribution of hipbelts weighing half this for loads under 40 lbs, so IMO it’s not weight well spent for UL loads.
2) The same goes for the Seek Outside frames. I think they are total overkill for 20 – 30 lbs loads when a couple lightweight frame stays can already transfer 100% of the load to your hips. If you want one to lug 40 – 50 lbs then sure, but adding an additional half pound of frame for UL loads is overkill. I very much disagree that adding a half pound here is achieving a net improvement in overall body stress when carrying a UL load.
3) The Zpacks trampoline back has the advantage of cooling your back, but I think this advantage is small and far outweighted by the much larger negative effect it has on posture. Less sweating on the back is nice, but I routinely get a sore back when I use trampoline packs for moderate loads on all day hikes, so the downsides outweigh the upsides. The physics back this up – moving the load away from your back unavoidably causes you to lean forward more, which puts more of the strain on your muscles and connective tissue, and less on your skeletal system. It’s one of those things where the benefits are immediate and noticeable, while the negatives are more subtle, so folks rave while IMO making a poor overall decision. With that said, it may be justifiable for very sweaty hikers that might otherwise chafe, or in very hot climates.
My overall philosophy is that you want a pack with enough frame and cushioning to transfer the loads you will be commonly carrying (which isn’t much for UL loads). So you want to avoid excessive sore spots. However, this needs to be balanced with the overall weight because adding features adds weight which adds wear on your legs that isn’t an acute effect like sore spots, but has larger but more subtle chronic effects on your body. So basically I want the lightest pack that will do the job. More “comfort” isn’t always better because it has other downsides.
As an extreme example, folks lugging 7 lbs Dana Designs packs with massive frames and huge padding routinely claim that their packs are the utmost in comfort and yet they seem far more beat up at the end of the day. They think they are choosing comfort, but evidently they are not. Of course there is more than just the pack here since the loads inside the packs are different too, but it’s important to remember that regardless of how wonderfully the load is transferred, your legs are still carrying that weight with every step and a half pound does add up to more cumulative fatigue. Thus you want enough frame and padding for the task at hand, but more isn’t always better. IMO, It’s not maximizing comfort irrespective of weight, it’s achieving reasonable comfort for the lowest weight.
To be clear, I’m not saying the SO Divide and many other heavier packs are bad packs – they have their appropriate uses – but I think they are suboptimal for UL loads. If you want one because you sometimes carry 50 lbs and think that versatility is worth a suboptimal pack when you’re carrying 25 lbs, then that’s a reasonable compromise.