Re. tape:
The tricky thing about taping over sewn seams is managing what carries the load.
As a seam is loaded, it stretches. This is due in part to the fibers in the fabric and thread stretching, but also to various bends and curves in the fabric near the seam straightening out. If you just casually lay the seam flat and tape over it, those bends will be trapped by the tape and won’t be able to straighten under load. This means the tape will take the full load. This isn’t necessarily bad, as there are many claims that taped seams are stronger than sewn, but sewing doesn’t suffer delamination over time as tape can. And if the tape is doing all the work, it begs the question, why sew? I once asked Joe at ZPacks that question and his response was, “in case the tape fails”.
In order for the sewn seam to share the load with the tape, you have to tension the seam before applying the tape. Clamping is probably the most effective, but tightly stuffing the pack is easier.
If your only interest is waterproofing, consider sticking w/ sealant. Cuben is a polyurethane (PU) laminate, so any PU (not silicone) seam sealer will work. Do some searching for tips and tricks on using sealant.
Re. fabric:
This is ultimately up to you, depending on what you want from the pack. Look at what other packs of similar size and design use. Given your stated influence by the HMG line, consider copying their fabric selection. Given your volume and use of frame, you have the potential for some heavy loads – I’d go w/ the hybrid cubens, especially on the bottom. The funny thing about that, since the lightest hybrid (50D) weighs 3osy, is that you’ll be in the same weight range as woven fabrics.