I think like for any other pack issue it depends a lot on other aspects of individual fit. My husband, age 62, has 3 fused joints (4 adjacent vertebrae) from two surgeries in his lumbar area, and 2 fused joints (3 adjacent vertebrae) in his cervical area. His discs don’t rupture they just disappear. He has been stable for a few years now. Over the last 15 years he’s gone from a REI Mars 80, then Osprey Atmos 65 (an older model), Exos 58 (2010), and now carries a GG Mariposa (2014). He says the Mariposa, rather than impinging on his back, seems to stabilize it when the hip belt is snugged in. He also has trouble with his prominent collarbones chafing under shoulder straps, and the Mariposa seems to do this less than the other models he’s carried. I’ve worked with him to redistribute his load within the pack too. Spatial arrangement isn’t his strong suit, and without my intervention he has trouble getting everything close enough to his spine to avoid the pull-back which can leave his neck and shoulders sore. Because of the back trouble he has to avoid heavy lifting (the non-backpack kind like carrying furniture) and he has to avoid running. But he says backpacking actually feels beneficial. We talked to Mr. McHale on the phone once, back when the pack was the Exos 58, about whether we should consider one of his packs, and he was able to offer useful suggestions for making the Exos more comfortable for the neck and collarbones, including using strap padding (in our case, old wool socks) with a gap cut out for the collarbone on each side.
The main thing would be, to find a light pack model that has a good solid wrap around the hips and lower back, and that otherwise fits well through the torso–ie long enough–and shoulders, to get a good load transfer, and then be careful not to pack it with too much weight towards the outboard direction, and instead bring everything in as close to your spine as you can get it.
I am not a pack maker or a medical professional but I do pack fitting and adjusting at work at REI and also lots of pack adjusting for the Camp Fire teens on my volunteer job.