13 years ago the standard Grand Canyon river guidebooks rated major rapids at a variety of flows, some pretty high. My books are buried in the basement or I'd confirm.
I've talked to guides who ran the river in the early 1980s when it ran 50,000 to 100,000 CFS for extended periods. They had no guidance!
They were forced to camp so high that they found the trash from early (pre-Glen Canyon Damn) river runners who routinely boated on flood flows. The average pre-dam flood through the Grand Canyon was roughly 100,000 CFS.
A well-known Colorado River scientist once said "45,000 CFS is a pretty wimpy flood," referring to one of the first high-flow experiments.
Every rapid responds differently to lower or higher flows than "normal". Some get harder, some get easier, some are unrecognizable. At extremely high flows, some gnarly rapids appear where none was seen at lower flows. This is true on every river, not just the Colorado through Grand Canyon.
One one trip we scouted Horn Creek, checked the guidebook, and read "Not recommended below 8,000 CFS".
"What's the flow?" "About 5,000 for the next week." (Another experiment in progress.) "Now what?"
As for campsites: during high flows, low-lying campsites will be underwater. After high flows, some campsites will be washed away (erosion), others will get bigger (deposition). Hard to predict, that's why they're called experiments.
— Rex