Well, that depends. The Steripen Journey/Opti is great for 2 week trips. It has held up since it was introduced. I worry around rocks, or with mishandling, but it seems reliable. I had an older Journey with the metal contacts that worked well, too. The trick is to flip one of the batteries with every use. Otherwise, the trickle current drain will kill the batteries prematurely. They still haven't changed over to a mechanical switch to prevent this. They have their reasons, I guess.
I always bring a couple small 1/2oz bottles of AM drops as backup. Roughly 1.5oz counting the bottle weight for both parts. This is about a week's supply of drinking water.
I boil water in the morning. Soo, I use dirty water for breakfast, around three 10oz cups. I make the same or a bit more at night, 2 for meals, one for cocoa and scotch.
I carry two gatoraid bottles, each 500ml. On the PCT, I might map out what I need because there are a few stretches you need to carry a day or twos worth. Usually this is some type of Platy bladder.
As far as resistance or immunity to Gardia, about 1/3 of the population is fairly immune to it and only suffer symptoms for a day or two. I cannot find any clear answer on resistance, or, if it is possible to build up an immunity. I sort of doubt it, since you have a hard time with other parasites.