I've always argued comfort is an important consideration both ways. I could walk around in body armor. It is legal pretty much everywhere, and I don't have to be a good shot to use it. Its also pretty uncomfortable so only soldiers and police use it.
On the other hand "someone" I know slept with an airweight .357 (12oz) loaded with very heavy loads while camping in grizzly country (bear spray won't go through tent walls).
I look at protection as a "comfort" item just like a thick pad. If a place is so dangerous you can only consider yourself truly safe with a gun I question the wisdom of going there. We don't do recreational backpacking in Afghanistan after all. On the other hand if light pistol helps you sleep better at night go ahead and pack it.

