Yes, I learned that the hard way last year. I decided to try trail running with a pair and developed bursitis in one heal from over doing it. both Achilles became very swollen as well.
It may have been because of the running though and not the shoes but more likely the combination. I had not run in awhile and was bicycle racing for years before.
I slowly transitioned back to them over the last 8 or so months wearing 4mm drop shoes most the time, which I think is what the NB I bought are. I also got some Pure Grit II in case the mt10 were not protective enough but ended up not wearing them for any of the hikes or backpacking I did.
both my wife and I were amazed how much less perceived effort we felt as well as the fact we simply did not think about our feet during or after a long days backpacking through rugged terrain.
Grip and stability were notably increased.
I liked the massage like feel I received through all the rocks. Especially the big, round rocks on the arch, sorta like rolling out the plantar fascia.