"what would be the best way to get into Keweah Basin for a couple of guys that arent super experienced with high / steep passes or cross country? Is it even advisable?"
Kaweah Basin is probably not the best place to earn your chops; however, if you are in the area and want to give it a try, by all means do so. That said, Pyra-Queen Col, the route you are referring to between Kaweah Queen and Pyramidal Pinnacle, not Black Kaweah, is most definitely not the place to get your feet wet. It is the most difficult of the commonly used routes that I know of and not for beginners. If you are coming from 9 Lakes Basin, I'd advise continuing on down the HST to Chagoopa Creek and following it up to Kaweah Pass. The approach to the pass from the HST is easy, but once over the pass you will have to descend a steep, loose scree slope. From there on, it is easy hiking, with the entire basin spread out before you. Since you are not experienced, it would be better for you to return the way you came, rather than attempting either of the routes that take you down to the Kern Kaweah River. They both require good route finding skills, and a comfort level with scrambling on occasionally exposed rock if you choose to descend the unnamed east fork of Pickett Creek. I hope this helps.
Edited for content: If you have Secor's "The High Sierra", look up Kaweah Pass. He has a pretty good description of what is involved. His description of Pyra-Queen Col is understated, to put it mildly.
Best of luck. You will be visiting a very special place.