I have three Thermarest mattresses and all, I'm sure, likely have some mold or other nasty "growth" in them from the bacteria in my breath. I doubt if the mold or other bacteria in the mattresss breaks down the foam or glue but it IS possible.
My solution for partially avoiding this is to lay my mattress out on my back yard after a trip with the valve open and let the sun's warmth drive out the moisture.
OK, I live in Las Vegas in the Mojave Desert where humidity is low and the sun can be hottt. But a warm, sunny day in most places in the world should be warm enough to do the trick.
Or am I just engaging in wishful thinking? Anyone else do this?
update:
STORAGE> Since many have remarked on storage, yes, all my Thermarests lie flat on a shelf in my laundry room with the valves open. I've always stored them like that.
SUN EXPOSURE> Good point on UV degredation of the fabric. I'll spray my mattress with "303 Protectant" B/C it's the best UV protectant I know. BUT, I'll still lay them out in direct sunlight for an hour after a trip.
Valve down is a good idea.

