Usain Bolt might disagree with the black magic comment above… There are all kinds of advances and inventions that add efficiency to the way humans operate. The natural way isn't alwasy the most efficient, so that's a pretty weak argument.
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Don't understand that. Bolt isn't from Africa, isn't a distance runner, and runs in minimalist spikes… no cushioning, just a spike plate. The black magic of marketing has made him one of the highest paid athletes on earth buy selling a bunch of junk most people don't need… and he could probably run just about as fast barefooted.
Anyway, back on topic. For the last 3+ years I have been hiking mostly in less than minimalist shoes; XC flats. No rock plate, minimal cushioning, heel drop of 5mm or less, and I buy them at least one size large. And I have worn out several pairs. During this time I have had zero blisters, unless you count the one impact bruise that turned into a blister… but that went away after hiking more than 40 miles in the two days after the injury.
Ancient man (includes women), for the most part, walked everyday. But it is was probably uncommon for most of them to walk more than 20 miles in a day. He normally did not wear shoes except maybe in winter to keep his feet warm or sometimes when traveling over difficult terrain. When one goes barefooted a lot, blisters can't happen on the bottom of your foot. Our ancient man was not overweight. Put all this together over hundreds and hundreds of thousands of years and the foot structure was optimized.
Now today many of us are overweight, we don't walk everyday, we never go barefooted, and then we expect footwear to compensate for a lifestyle that is incompatible for efficient walking/backpacking.
So… walk every day, get your weight down so you are lean, and walk barefooted a bit everyday. Then you won't need fancy shoes. A light, thin, flat shoe will serve you well. Just make sure they are big enough or even too big. All those "advances and inventions that add efficiency to the way humans operate" are just compensations for the root cause problem… sitting on our butts too much.

