Everyone else's mileage may vary but two solutions I see to be able to fell most of the seams on a pack:
1) I am using a single continuous piece of fabric for the front / bottom / back of my pack, so there are less seams to deal with. But I agree with the earlier poster about sewing the side seams up only partially, then stopping and going back to fell the bottom seams before continuing the close up the sides of the pack.
2)The other is something I did this weekend; sewing the backpanel to both of the side panels FIRST before sewing the sides the front panel. This allowed me to easily get to that area to do felled seams. I also did them in such a way that the seam faces toward my back so are essentially unseen from the front which is good cus they aren't perfect. Then I moved on to attaching the side panels to the front panel. At that point it was a cylinder so I won't be able to get at those the same way, so those will just get grosgrain to finish the raw edges and be the only non-felled seams on the pack.
Though I am also thinking it might be better than not, to do a felled seam just the last 6 inches or so of the top of the pack (since its easy get to) for the strength it should add.