But I don't wear liners with any footwear including mountaineering boots and ski boots.
I like the Smartwool PhD light and ultralight running socks for trail runners — the ones that just cover the ankle usually. I need to decide on exact sock thickness when I decide on the shoe though. I am still sussing out "waterproof" socks and will probably use a "liner" in them. (I have not had much luck with GTX trail runners!) Of course, that arrangement will need dedicated bigger shoes! Depending on the shoe and the fit, a liner weight sock may be all you want to wear.
Just use a little bit of salve or body glide (there's a "dry" version of this that comes in "single use" packs that is enough for a week — packs aren't resealable and the stuff is a bit of a mess — otherwise it's a great product) in places prone to "blister" — before you get in trouble. But don't muck up open sores with the stuff. Once you use this stuff, you'll have to wash the feet with soap before you'll get any sort of dressing to stick.
When you are shower clean, you can use something like Eucerin ointment covered in a sock at night every so often to keep the skin from drying out and cracking. Again, don't muck up dirty lesions with grease! BTW, Eucerin ointment is awesome stuff! And it comes in 2 packs of little tubes (1/2 oz tubes, I think) in addition to larger tubes.
I always have a few alcohol swabs and lancets (in the diabetes supply section of your local drugstore). Say 20 gauge hollow needles would be better — there is something about seeing the blister juice ooze out the top!– but are harder to come by. Clean and lance before the skin tears. Then cover with a nonstick dressing. Don't put duck tape, leukotape, rock tape (so cool!), kinesio tape or whatever BPL's tape of the moment is directly against blisters — you'll rip the skin on removal.