Down will be lighter per warmth if in the 650-900 ci/oz range, it stuffs smaller and lasts longer. I have a down bag that I have had since the late 70s and it still has 90% of its loft. Down will wet out faster but since the advent of superb DWRs its a whole different story. If it ever gets totally wet then it is very hard to dry out in the field. The trick is to not let that happen. Just set up your pack so if you take a fall in a river your bag and cloths will stay dry.
Also for me, I dont know about everybody else it just feels better climbing into a down bag.
That said I have been in extremely humid-rainy-foggy weather, years ago, hoovering around freezing for about a week straight and my down bag delofted a small amount every day, but never wetted out and I still stayed very warm.
That was back when there were no DWR coatings.
A few winters ago I slept out unprotected in the open with a montbell bag at about 40dF. Heavy fog and dew that night.
As soon as the sun hit the bag it was totally dry in 10 minutes. That was my 1st experience with DWR and I was amazed how fast it dried. DWR is great stuff on a sleeping bag.
Now as far as synthetics, all will be more bulky packed than down bags and that is a big drawback to me.
I will say if you are in someplace like South Florida where it is 90% humidity all the time, or a rain forest etc, I would recommend synthetics over down. Those types of environments are just wet all the time. I am sure a modern DWR down bag would do fine, but I would prefer synthetic in those conditions.
Also maybe if you are in sub zero conditions 24/7 then down can have issues as the condensation side is inside the down chambers, and moisture will continually form and freeze inside your bag eventually delofting it but a synthetic topper would cure that. Another issue is a -20dF synthetic bag is going to be very heavy compared to a high quality down bag.
Climashield is about equal to 550 down in warmth to weight and climashield is about as good as it gets for synthetic insulation.
Synthetics eventually break down and lose loft and especially fast if you stuff the $%^& out it and super compress it continually like in a compression bag.
Its best just to let it lay in the bottom of your pack. Same with down though. Over compressing anything is no good.
A particular favorite of mine is the golite ultra 20 down quilt. 20oz, good to 20dF and stuffs to about the size of a Football.
Wet areas where I would rather have a synthetic bag…
Anywhere that has constant high humidity and rain.
Tropics, Everglades, Pacific Northwest, Patagonia, Basically any rain forest.
Thats about all I can think of for now.
For moderate and or warm weather and you can do a MYOG 45dF climashield quilt at about 14oz for about $110.
For a little more $ a 25-30dF climashield quilt at about 22 oz.