Fieldwork is the only way to answer this question. Otherwise you risk biased conclusions based on romanticized images of what a healthy life is and various other persuasions. I will share what I have learned, and maybe others thru-hikers can do the same.
I would love to believe that thru-hiking promotes longevity and happiness, but a year and a half after my PCT thru-hike, there’s still a brief moment of tenderness every morning when I first get on my feet. At least two other veteran PCT thru-hikers related to me that they had this for a year or more after their thru-hike.
For a month after returning home, it was painful to run. My legs and particularly knees felt stiff and hurt upon impact. Then it went away.
I believe Ray Jardine when he writes that the body becomes weaker as a thru-hike progresses. Minerals run low. Long-term muscle fatigue sets in. I talked with someone on the PCT who had participated in a study of AT thru-hikers. The study, run by Alma College students, found that after 500 miles hikers had the cardiovascular indicators of elite athletes, but made essentially no further fitness gains.
As for the emotional effects, I think that for most modern Homo Sapiens the effect will be positive compared to their normal lifestyles. However, two people can leave the border on the same day and arrive in Canada on the same day, and yet one will have spent 95% of his hike among people, and the other just 5%.
Thru-hiking also lowers reproductive function:) You’ll find a negative correlation between the number of hiking miles under someone’s belt and the number of children they have. But is that correlation or causation?:)
I loved my thru-hike and will do it again.

