Cory,
To be honest, I haven't used the desktop version of RouteBuddy either. My recommendation was based on my experience with their iPhone app, which has by far the best-scanned USGS maps of any desktop or mobile phone I've used, and the screenshots from their website.
I downloaded the demo version of the desktop, and indeed it is fast and intuitive. Unfortunately there are many missing features. You cannot draw a route; it's just waypoint-to-waypoint. But the biggest issue, which is unfortunately a deal-breaker, is the lack of any real printing function. You cannot overlay a UTM grid, it doesn't print compass info or degrees at all, and worst of all, it only prints the visible area on your screen, leaving bands of white space on the paper if you use a widescreen monitor. Obviously this was designed for road map use first. It's too bad, because in terms of fast, simple software and high quality maps, no one can beat RouteBuddy IMO. I will watch them closely for software updates.
Chris,
Garmin has a nice product; $129 for the Western states is actually a good deal. Just keep in mind that they are not official USGS topo maps. You will find much more detail on USGS topo maps than you will on Garmin maps. For example, a USGS topo map will show you water towers, mines, buildings, springs, etc. Garmin has a nice product, I just wish they would include all of these, since they can be useful in locating yourself an exploring the area.