It doesn't have to be rocket science. Here are a few tips:
When talking about digital, copying doesn't lose quality unless you are encountering things like scratches in DVDs.
Cost per GB may lean to DVDs but for reliable backups harddrives still win due to degridation in films used on the DVD, and lets face it, scratches happen.
If form factors of harddrives change (such as IDE to SATA) there will always be connectors on the market.
Firesafes aren't usually waterproof.
Even if a firesafe protects the drive from burning, the air in the safe reaching 1,500 degrees will ruin the drive data and melt the plastic parts.
It took twenty years for IDE to go by the wayside for SATA, and most motherboards still support it. It may not be as fast as current technology but generally hard drives have a very slow form factor change over, so you'll at least be able to read those drives, or have plenty of forwarning allowing you to copy them to a new drive type.
Online backups make a good affordable off-site that can be automated, but must not be your only backup as these companies occasionally go out of business overnight (happened to me, lost a ton of accounting files).
Automated backups are worth setting up.
Learn about incrimental types of backups. You don't need daily backups of the same unchanged files. Good software should have lots of ways of just grabbing periodic full backups while backing up changed and new files much more frequently.
Off-site storage is mandatory but doesn't have to be anything more than handing a harddrive to a friend or family member in an anti-static bag and having them put it in their closet. When disaster happens the one thing most people can't replace is their photos.
Solid state drives look promising but aren't there yet for archiving. The cost / gb is still high and readers are not as universal as one thinks. Formfactors change in solid state drives about every five years as well. Even SD cards have changed with the new larger cards being unreadable in older readers.