Kai,
I recently returned from 1.5 months of backpacking, packrafting, and fly fishing. I used one pair of shoes for everything and just varied my sock combination based on the environment. My shoes were Five Ten Savants (31 oz for size 11.5); they have the same sticky rubber soles and quick draining mesh as the heavier Five Ten Canyoneers but better foot cushioning for backpacking. In an earlier thread I posted my wet friction tests and the Five Ten Canyoneer’s sole(same as Savant’s sole) came out on top. After a run through the washing machine they still look near new.
Socks for backpacking and creek crossings were Silvermax liners (odor prevention) and Serius Gen II Storm socks (2.0mm). For extended river wading, I just added a pair of 2 mm Cabela's neoprene as the outside sock pair. For camp use I used a pair of Smart Wool socks with Cabela's Gore-Tex socks over them. For sleeping I just took off the Cabela's Gore-Tex sock and wore the Smart Wool socks to bed. My feet were always comfortable and my shoe weight was the lowest.
For two weeks of my 1.5 month trip I was with 4 other people who brought multiple pairs of shoes. Two of them brought Crocs for camp wear and dual-sole Krokers for fly fishing / backpacking. Like me, they used Silvermax liner socks and two pair of 2mm neoprene socks for river wading. They used Smart Wool socks with their crocs for camp wear. We were in and out of the rivers and scrambling rocky canyons so often they just ended up just leaving the felt soles on their Krokers all of the time. Their 8 oz hiking soles were only used on the initial backpack in. Their felt soles were shot after the two weeks of combined trail and river use.
Two of the others brought felt soled boots for river wading and trail runners for backpacking and camp use. I don’t recall what they brought for socks. One of the two didn’t account for his feet swelling and softening from the river wading and frequent rock scrambling. After a few days he put on his normally good fitting trail runners to climb up to a mountain peak for the views and came back very badly blistered.