Bought some mids that seemed to fit well, and broke them in with several day hikes. Then took them for a backpack in the Never Summer wilderness. After a day, realized that the toe boxes were too narrow, pushing the second toe into the big one. The large blister was full of white puss and the pain getting worse, but really did not want to bail. So made a cut in the blister just large enough to drain the wound. Then crushed some iodine water purification tablets into fine powder, and rubbed it into the wound, and bandaged to stop the rubbing against the big toe. The pain was soon gone.
Based on the Doc’s post, if the blister had already broken, would have irrigated it first with purified water from my home made pump filter that uses a Sawyer mini and a ketchup pump, idea courtesy of David Smith. The wound was healed by the end of the 5 day hike. The mids went into the trash.  Also carry a mini PLB, and would have used it if the wound had not cleared up. Have only had to use one once. Note: The deputy sheriffs really appreciate it if you can get to a trailhead or other accessible spot before pulling the plug, but would not delay if the wound were life threatening like those described by the good doctor.
