All the information on chlorine dioxide treatment is out there for you to google. Time x concentration curves and log reductions.
Nothing is 100% safe.  Its all relative reduction. 99.99, 99.999, 99.9999, etc.
EPA requirements to be called a water purifier……require huge reduction in highly tainted water…10e-5 to 10e-6. Water quality that you’re unlikely to ever encounter in the backcountry.
Viruses and bacteria are effctively killed in a minute
Giardia……reduced 1000 fold in 15 minutes. when you consider you’re probably only going to get a concentration of a few cysts per liter, how much reduction do you need? 25% of people also are already infected with giardia asymptomatically, so theres that.
Cryptosporidium is the tough one….4 hrs…..Nobody ever waits for it, and nobody ever has any problems.  It’s just really not an issue in backcountry water. If drinking cattle runoff……wait.
Treatment efficacy depends on time x concentration. 2 ppm for 8 hrs is equivalent to 4 ppm for 4 hrs is equivalent to 8 ppm for 2 hrs. You can always use more or less and affect the treatment times needed as well.  Which is reason a lot of people use AM drops