Yes the nylon side is as usual as any “common” fabric so it can’t be sealed. If you mean to add waterproof to the pack, I think all the stitches on a HMG pack is covered with a cuben tape to resist water from the inside of the pack (the DCF side of the hybrid cuben).
The only exception is the pack’s bottom circle of stitches that are not flat and covered with a non-DCF strip. Water may come in from the bottom seal of the outside pockets, but will go between the layers, since the pack’s bottom has two layers of DCF?