From a cold sleeping, comfort seeking woman’s point of view, there are two issues here. One is comfort and support, which is beautifully handled by the Big Agnes (the most comfortable air mattress on which I have slept) and insulation from cold, which the Thermarest Prolite3-Womens mattress provides. The combination is unbeatable, but not for lightweight backpacking. Your wife needs to determine whether she values comfort over cold.